The genus curcuma and inflammation: overview of the pharmacological perspectives
UNIVERSAL IDENTIFIER: http://hdl.handle.net/11093/1920
EDITED VERSION: https://www.mdpi.com/2223-7747/10/1/63
UNESCO SUBJECT: 3209 Farmacología ; 5101.13 Medicina Tradicional ; 3309.20 Propiedades de Los Alimentos
DOCUMENT TYPE: article
The Curcuma genus has been extensively used for therapeutic purposes in traditional or folk medicine worldwide, including for its anti-inflammatory activity. Curcuma spp.’s active constituents, such as alkaloids, flavonoids, and terpenoids, can act on various targets in the signaling pathway, restrain pro-inflammatory enzymes, lower the production of inflammatory cytokines and chemokines, and reduce oxidative stress, which subsequently suppresses inflammatory processes. Preclinical and clinical studies have reported the predominant anti-inflammatory activity of several Curcuma species. This review provides an overview of the anti-inflammatory effects of different extracts, preparations, and bioactive components in this genus. This analysis may provide a scientific basis for developing new and alternative methods for the isolation of a single entity from this genus to attenuate inflammatory conditions. The Curcuma genus is waiting for researchers interested in developing safe and efficient anti-inflammatory agents for further investigation.
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