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dc.contributor.authorOmar, Faisal
dc.contributor.authorTareq, Abu Montakim
dc.contributor.authorAlqahtani, Ali M.
dc.contributor.authorDhama, Kuldeep
dc.contributor.authorSayeed, Mohammed Abu
dc.contributor.authorEmran, Talha Bin
dc.contributor.authorSimal Gándara, Jesús 
dc.date.accessioned2021-05-11T11:34:40Z
dc.date.available2021-05-11T11:34:40Z
dc.date.issued2021-04-15
dc.identifier.citationMolecules, 26(8): 2297 (2021)spa
dc.identifier.issn14203049
dc.identifier.urihttp://hdl.handle.net/11093/2123
dc.description.abstractPlant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads.spa
dc.language.isoengspa
dc.publisherMoleculesspa
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePlant-based indole alkaloids: a comprehensive overview from a pharmacological perspectiveen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/molecules26082297
dc.identifier.editorhttps://www.mdpi.com/1420-3049/26/8/2297spa
dc.publisher.departamentoQuímica analítica e alimentariaspa
dc.publisher.grupoinvestigacionInvestigacións Agrarias e Alimentariasspa
dc.subject.unesco2302.01 Alcaloidesspa
dc.subject.unesco3209.07 Fitofármacosspa
dc.subject.unesco3209.03 Evaluación de Medicamentosspa
dc.date.updated2021-05-11T07:27:34Z


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    Except where otherwise noted, this item's license is described as Attribution 4.0 International