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dc.contributor.authorGambino, Tanja
dc.contributor.authorValencia Matarranz, Laura Maria 
dc.contributor.authorPérez Lourido, Paulo Antonio 
dc.contributor.authorEsteban Gómez, David
dc.contributor.authorZaiss, Moritz
dc.contributor.authorPlatas Iglesias, Carlos
dc.contributor.authorAngelovski, Goran
dc.date.accessioned2021-06-21T11:25:44Z
dc.date.available2021-06-21T11:25:44Z
dc.date.issued2020
dc.identifier.citationInorganic Chemistry Frontiers, 7(12): 2274-2286 (2020)spa
dc.identifier.issn20521553
dc.identifier.urihttp://hdl.handle.net/11093/2277
dc.description.abstractWe report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST (paramagnetic chemical exchange saturation transfer) contrast agents. The investigated europium(III) chelate is non-hydrated and contains four amide groups, each possessing two paramagnetically shifted proton resonances distant from bulk water. The X-ray crystal structure and solution studies indicate that the metal ion is ten-coordinated, being directly bound to the six N atoms of the macrocycle and the four amide O atoms of the pendant arms. The complex presents an excellent inertness with respect to dissociation, being stable under a variety of harsh conditions, including highly acidic and basic media or elevated temperatures. The amide protons are in slow-to-intermediate exchange with bulk water, which gives rise to the generation of a strong CEST effect at low probe concentration and saturation powers (∼25% at 5 mM, B1 = 5 μT, 37 °C). We demonstrate the potential of this platform for mapping pH in its microenvironment and foresee potential for the development of diverse paraCEST probes and sensorseng
dc.description.sponsorshipMinisterio de Economía y Competitividad | Ref. CTQ2016-76756-Pspa
dc.description.sponsorshipXunta de Galicia | Ref. ED431B 2017/59spa
dc.description.sponsorshipXunta de Galicia | Ref. ED431D 2017/01spa
dc.description.sponsorshipGerman Research Foundation | Ref. DFG, grant ZA 814/2-1spa
dc.description.sponsorshipEuropean Union’s Horizon 2020 | Ref. Grant Agreement N. 667510spa
dc.language.isoengspa
dc.publisherInorganic Chemistry Frontiersspa
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.titleInert macrocyclic Eu 3+ complex with affirmative paraCEST featureseng
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.1039/C9QI01612K
dc.identifier.editorhttp://xlink.rsc.org/?DOI=C9QI01612Kspa
dc.publisher.departamentoQuímica inorgánicaspa
dc.publisher.grupoinvestigacionNanoBioMateriais Funcionaisspa
dc.subject.unesco2303 Química Inorgánicaspa
dc.subject.unesco2207.16 Resonancia Magnética Nuclearspa
dc.subject.unesco2304 Química Macromolecularspa
dc.date.updated2021-06-21T10:41:59Z


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