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dc.contributor.authorAndleeb, Anisa
dc.contributor.authorAndleeb, Aneeta
dc.contributor.authorAsghar, Salman
dc.contributor.authorZaman, Gouhar
dc.contributor.authorTariq, Muhammad
dc.contributor.authorMehmood, Azra
dc.contributor.authorNadeem, Muhammad
dc.contributor.authorHano, Christophe
dc.contributor.authorLorenzo Rodríguez, José Manuel
dc.contributor.authorAbbasi, Bilal Haider
dc.date.accessioned2021-11-29T12:41:25Z
dc.date.available2021-11-29T12:41:25Z
dc.date.issued2021-06-05
dc.identifier.citationCancers, 13(11): 2818 (2021)spa
dc.identifier.issn20726694
dc.identifier.urihttp://hdl.handle.net/11093/2767
dc.description.abstractCancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus far; however, conventional chemotherapeutic drugs have lower bioavailability, rapid renal clearance, unequal delivery, and severe side effects. In the recent years, nanotechnology has flourished rapidly and has a multitude of applications in the biomedical field. Bio-mediated nanoparticles (NPs) are cost effective, safe, and biocompatible and have got substantial attention from researchers around the globe. Due to their safe profile and fewer side effects, these nanoscale materials offer a promising cure for cancer. Currently, various metallic NPs have been designed to cure or diagnose cancer; among these, silver (Ag), gold (Au), zinc (Zn) and copper (Cu) are the leading anti-cancer NPs. The anticancer potential of these NPs is attributed to the production of reactive oxygen species (ROS) in cellular compartments that eventually leads to activation of autophagic, apoptotic and necrotic death pathways. In this review, we summarized the recent advancements in the biosynthesis of Ag, Au, Zn and Cu NPs with emphasis on their mechanism of action. Moreover, nanotoxicity, as well as the future prospects and opportunities of nano-therapeutics, are also highlighted.eng
dc.language.isoengspa
dc.publisherCancersspa
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleA systematic review of biosynthesized metallic nanoparticles as a promising anti-cancer-strategyeng
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/cancers13112818
dc.identifier.editorhttps://www.mdpi.com/2072-6694/13/11/2818spa
dc.publisher.departamentoEnxeñaría químicaspa
dc.subject.unesco3207.03 Carcinogénesisspa
dc.subject.unesco3208.06 Quimioterapiaspa
dc.subject.unesco3209.90 Farmacología Experimentalspa
dc.date.updated2021-11-29T11:51:28Z


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    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International