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dc.contributor.authorNoriega-Rodríguez, Diana
dc.contributor.authorSoto Maldonado, Carmen
dc.contributor.authorTorres Alarcón, Cristian
dc.contributor.authorPastrana Castro, Lorenzo Miguel 
dc.contributor.authorWeinstein Oppenheimer, Caroline
dc.contributor.authorZúñiga Hansen, María Elvira
dc.date.accessioned2021-02-09T13:24:59Z
dc.date.available2021-02-09T13:24:59Z
dc.date.issued2020-06-20
dc.identifier.citationProcesses, 8(6): 715 (2020)spa
dc.identifier.issn22279717
dc.identifier.urihttp://hdl.handle.net/11093/1763
dc.description.abstractGlobe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells.spa
dc.description.sponsorshipComisión Nacional de Investigación Científica y Tecnológica (CONICYT) | Ref. R15F10006spa
dc.description.sponsorshipBiotechnologies to Valorise the regional food Biodiversity in Latin America (BiValBi) | Ref. FP7 IRSES 611493spa
dc.language.isoengspa
dc.publisherProcessesspa
dc.rightsCreative Commons Attribution (CC BY) license
dc.rightsCreative Commons Attribution (CC BY) license
dc.rightsCreative Commons Attribution (CC BY) license
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.uri
dc.source.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleValorization of Globe Artichoke (Cynara scolymus) agro-industrial discards, obtaining an extract with a selective effect on viability of cancer cell linesspa
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/pr8060715
dc.identifier.editorhttps://www.mdpi.com/2227-9717/8/6/715spa
dc.publisher.departamentoQuímica analítica e alimentariaspa
dc.publisher.grupoinvestigacionInvestigacións Agrarias e Alimentariasspa
dc.subject.unesco3309.03 Antioxidantes en Los Alimentosspa
dc.subject.unesco3201.01 Oncologíaspa
dc.subject.unesco3309.20 Propiedades de Los Alimentosspa
dc.date.updated2021-02-05T11:50:12Z
dc.computerCitationpub_title=Processes|volume=8|journal_number=6|start_pag=715|end_pag=spa


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