The strategic alliance between clinical and molecular science in the war against SARS-CoV-2, with the rapid-diagnostics test as an indispensable weapon for front line doctors
Gaddi, Antonio Vittorino; Capello, Fabio; Aluigi, Leonardo; Antignani, Pier Luigi; Callegaro, Annapaola; Casu, Gavino; Cipolla, Enrico; Cipolla, Maurizio; Cosco, Lucio; Culzoni, Federico; Dentali, Francesco; Elexpuru Zabaleta, María; Forbes Hernández, Tamara Yuliett; Fragiacomo, Claudia; Giampieri , Francesca; Gnasso, Agostino; Mancini, Raffaele; Modena, Maria Grazia; Nichelatti, Michele; Paradiso, Angelo Virgilio; Ortasi, Pasquale; Savo, Maria Teresa; Tangianu, Flavio; Tempesta, Sergio; Voci, Tommaso Diego; Battino , Maurizio
UNIVERSAL IDENTIFIER: http://hdl.handle.net/11093/1764
EDITED VERSION: https://www.mdpi.com/1422-0067/21/12/4446
DOCUMENT TYPE: article
Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.
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