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dc.contributor.authorCarpena Rodríguez, María 
dc.contributor.authorNúñez Estévez, Bernabé 
dc.contributor.authorSoria Lopez, Anton 
dc.contributor.authorSimal Gándara, Jesús 
dc.date.accessioned2021-04-23T08:45:27Z
dc.date.available2021-04-23T08:45:27Z
dc.date.issued2020-10-31
dc.identifier.citationNutrients, 12(11): 3360 (2020)spa
dc.identifier.issn20726643
dc.identifier.urihttp://hdl.handle.net/11093/2010
dc.description.abstractBee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.en
dc.description.sponsorshipEuropean Union | Ref. 0181_NANOEATERS_01_Espa
dc.description.sponsorshipEuropean Union | Ref. 0377_IBERPHENOL_6_Espa
dc.description.sponsorshipXunta de Galicia | Ref. IN852A 2018/58spa
dc.language.isoengen
dc.publisherNutrientsspa
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleBee venom: an updating review of its bioactive molecules and its health applicationsen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/H2020/888003
dc.identifier.doi10.3390/nu12113360
dc.identifier.editorhttps://www.mdpi.com/2072-6643/12/11/3360spa
dc.publisher.departamentoQuímica analítica e alimentariaspa
dc.publisher.grupoinvestigacionInvestigacións Agrarias e Alimentariasspa
dc.subject.unesco3209.04 Medicamentos Naturalesspa
dc.subject.unesco5101.13 Medicina Tradicionalspa
dc.subject.unesco3104.01 Apiculturaspa
dc.date.updated2021-03-11T11:10:24Z
dc.computerCitationpub_title=Nutrients|volume=12|journal_number=11|start_pag=3360|end_pag=spa


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    Except where otherwise noted, this item's license is described as Attribution 4.0 International