dc.contributor.author | Herrera Pérez, Salvador | |
dc.contributor.author | Campos Ríos, Ana | |
dc.contributor.author | Rueda Ruzafa, Lola | |
dc.contributor.author | Lamas Castro, José Antonio | |
dc.date.accessioned | 2021-09-29T11:28:14Z | |
dc.date.available | 2021-09-29T11:28:14Z | |
dc.date.issued | 2021-06-21 | |
dc.identifier.citation | International Journal of Molecular Sciences, 22(12): 6635 (2021) | spa |
dc.identifier.issn | 14220067 | |
dc.identifier.uri | http://hdl.handle.net/11093/2531 | |
dc.description.abstract | Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome. | eng |
dc.description.sponsorship | Agencia Estatal de Investigación | Ref. PID2019-109425GB-I00 | spa |
dc.language.iso | eng | spa |
dc.publisher | International Journal of Molecular Sciences | spa |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Contribution of K2P potassium channels to cardiac physiology and pathophysiology | eng |
dc.type | article | spa |
dc.rights.accessRights | openAccess | spa |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109425GB-I00/ES/CANALES DE POTASIO DE DOBLE DOMINIO DE PORO (K2P-TREK) EN NEURONAS PARASIMPATICAS DEL GANGLIO INTRACARDIACO DE RATON | spa |
dc.identifier.doi | 10.3390/ijms22126635 | |
dc.identifier.editor | https://www.mdpi.com/1422-0067/22/12/6635 | spa |
dc.publisher.departamento | Bioloxía funcional e ciencias da saúde | spa |
dc.publisher.grupoinvestigacion | Fisioloxía Endocrina e Neurofisioloxía | spa |
dc.subject.unesco | 3207.04 Patología Cardiovascular | spa |
dc.subject.unesco | 3205.01 Cardiología | spa |
dc.subject.unesco | 2411.03 Fisiología Cardiovascular | spa |
dc.date.updated | 2021-09-29T11:06:49Z | |
dc.computerCitation | pub_title=International Journal of Molecular Sciences|volume=22|journal_number=12|start_pag=6635|end_pag= | spa |