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dc.contributor.authorHerrera Pérez, Salvador 
dc.contributor.authorCampos Ríos, Ana 
dc.contributor.authorRueda Ruzafa, Lola 
dc.contributor.authorLamas Castro, José Antonio 
dc.date.accessioned2021-09-29T11:28:14Z
dc.date.available2021-09-29T11:28:14Z
dc.date.issued2021-06-21
dc.identifier.citationInternational Journal of Molecular Sciences, 22(12): 6635 (2021)spa
dc.identifier.issn14220067
dc.identifier.urihttp://hdl.handle.net/11093/2531
dc.description.abstractYears before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome.eng
dc.description.sponsorshipAgencia Estatal de Investigación | Ref. PID2019-109425GB-I00spa
dc.language.isoengspa
dc.publisherInternational Journal of Molecular Sciencesspa
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleContribution of K2P potassium channels to cardiac physiology and pathophysiologyeng
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109425GB-I00/ES/CANALES DE POTASIO DE DOBLE DOMINIO DE PORO (K2P-TREK) EN NEURONAS PARASIMPATICAS DEL GANGLIO INTRACARDIACO DE RATONspa
dc.identifier.doi10.3390/ijms22126635
dc.identifier.editorhttps://www.mdpi.com/1422-0067/22/12/6635spa
dc.publisher.departamentoBioloxía funcional e ciencias da saúdespa
dc.publisher.grupoinvestigacionFisioloxía Endocrina e Neurofisioloxíaspa
dc.subject.unesco3207.04 Patología Cardiovascularspa
dc.subject.unesco3205.01 Cardiologíaspa
dc.subject.unesco2411.03 Fisiología Cardiovascularspa
dc.date.updated2021-09-29T11:06:49Z
dc.computerCitationpub_title=International Journal of Molecular Sciences|volume=22|journal_number=12|start_pag=6635|end_pag=spa


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    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International