Computational and pharmacological studies on the antioxidant, thrombolytic, anti-inflammatory, and analgesic activity of molineria capitulata
UNIVERSAL IDENTIFIER: http://hdl.handle.net/11093/2534
EDITED VERSION: https://www.mdpi.com/1467-3045/43/2/35
UNESCO SUBJECT: 3209.04 Medicamentos Naturales ; 3309.03 Antioxidantes en Los Alimentos ; 2302.21 Biología Molecular
DOCUMENT TYPE: article
Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.
Files in this item
- Shovo_MohammadAshiqur Rahman ...