Continuous‐flow preparation of benzotropolones: combined batch and flow synthesis of epigenetic modulators of the (JmjC)‐containing domain

Abstract

Continuous flow chemistry technology has been used for the formation of benzotropolone core, the main structural motif of a family of polyphenolic natural products that presents very interesting biological activities. The article describes a robust and efficient methodology to access this type of structures and further demonstrates the suitability of continuous flow processing for the preparation of a synthetic derivative that has been recently described as a potent epigenetic modulator