Continuous‐flow preparation of benzotropolones: combined batch and flow synthesis of epigenetic modulators of the (JmjC)‐containing domain
DATA:
2021-10-18
IDENTIFICADOR UNIVERSAL: http://hdl.handle.net/11093/2608
VERSIÓN EDITADA: https://onlinelibrary.wiley.com/doi/10.1002/slct.202102457
TIPO DE DOCUMENTO: article
RESUMO
Continuous flow chemistry technology has been used for the formation of benzotropolone core, the main structural motif of a family of polyphenolic natural products that presents very interesting biological activities. The article describes a robust and efficient methodology to access this type of structures and further demonstrates the suitability of continuous flow processing for the preparation of a synthetic derivative that has been recently described as a potent epigenetic modulator