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dc.contributor.authorAfrin, Sadia
dc.contributor.authorGiampieri, Francesca
dc.contributor.authorCianciosi, Danila
dc.contributor.authorÁlvarez Suárez, José Miguel
dc.contributor.authorBullón, Beatriz
dc.contributor.authorAmici, Adolfo
dc.contributor.authorQuiles, Josè L.
dc.contributor.authorForbes Hernández, Tamara Yuliett 
dc.contributor.authorBattino, Maurizio
dc.date.accessioned2021-11-25T13:04:48Z
dc.date.available2021-11-25T13:04:48Z
dc.date.issued2021-10
dc.identifier.citationFood and Chemical Toxicology, 156, 112484 (2021)spa
dc.identifier.issn02786915
dc.identifier.urihttp://hdl.handle.net/11093/2753
dc.descriptionFinanciado para publicación en acceso aberto: Universidade de Vigo/CISUG
dc.description.abstractColorectal cancer remains a challenging health burden worldwide. This study aimed to assess the potentiality of Strawberry tree honey (STH), a polyphenol-enriched food, to increase the effectiveness of 5-Fluorouracil (5-FU) in adenocarcinoma (HCT-116) and metastatic (LoVo) colon cancer cell lines. The combined treatment reduced cell viability and caused oxidative stress, by increasing oxidative biomarkers and decreasing antioxidant defence, in a more potent way compared to 5-FU alone. The expression of endoplasmic reticulum (ATF-6, XBP-1) and MAPK (p-p38 MAPK, p-ERK1/2) markers were also elevated after the combined treatment, enhancing the cell cycle arrest through the modulation of regulatory genes (i.e., cyclins and CDKs). Apoptotic gene (i.e., caspases) expressions were also increased after the combined treatment, while those of proliferation (i.e., EGFR), cell migration, invasion (i.e., matrix metallopeptidase) and epithelial–mesenchymal transition (N-cadherin, β-catenin) were suppressed. Finally, the combined treatment led cell metabolism towards a quiescent stage, by reducing mitochondrial respiration and glycolysis. In conclusion, this work represents an initial step to highlight the possibility to use STH in combination with 5-FU in the treatment of colon cancer, even if further in vitro an in vivo studies are strongly needed to confirm the possible chemo-sensitizing effects of STH.en
dc.language.isoengen
dc.publisherFood and Chemical Toxicology: 02786915spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleStrawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cellsen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.1016/j.fct.2021.112484
dc.identifier.editorhttps://doi.org/10.1016/j.fct.2021.112484spa
dc.publisher.departamentoQuímica analítica e alimentariaspa
dc.publisher.grupoinvestigacionAgroBioTech for Healthspa
dc.subject.unesco3207.13 Oncologíaspa
dc.subject.unesco2302.90 Bioquímica de Alimentosspa
dc.subject.unesco309.20 Propiedades de Los Alimentosspa
dc.date.updated2021-11-25T12:55:38Z
dc.computerCitationpub_title=Food and Chemical Toxicology|volume=156|journal_number=|start_pag=112484|end_pag=spa


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