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dc.contributor.authorRodrigues Amorim, Daniela
dc.contributor.authorRivera Baltanás, Tania
dc.contributor.authorVallejo Curto, María del Carmen
dc.contributor.authorRodriguez Jamardo, Cynthia
dc.contributor.authorde las Heras, Elena
dc.contributor.authorBarreiro Villar, Carolina
dc.contributor.authorBlanco Formoso, María 
dc.contributor.authorFernández Palleiro, Patricia
dc.contributor.authorÁlvarez Ariza, María
dc.contributor.authorLópez, Marta
dc.contributor.authorGarcía Caballero, Alejandro 
dc.contributor.authorOlivares, José Manuel
dc.contributor.authorSpuch Calvar, Carlos 
dc.date.accessioned2022-10-06T12:26:13Z
dc.date.available2022-10-06T12:26:13Z
dc.date.issued2020-08-31
dc.identifier.citationScientific Reports, 10(1): 14271 (2020)spa
dc.identifier.issn20452322
dc.identifier.urihttp://hdl.handle.net/11093/3923
dc.description.abstractSchizophrenia is a progressive disorder characterized by multiple psychotic relapses. After every relapse, patients may not fully recover, and this may lead to a progressive loss of functionality. Pharmacological treatment represents a key factor to minimize the biological, psychological and psychosocial impact of the disorder. The number of relapses and the duration of psychotic episodes induce a potential neuronal damage and subsequently, neurodegenerative processes. Thus, a comparative study was performed, including forty healthy controls and forty-two SZ patients divided into first-episode psychosis (FEP) and chronic SZ (CSZ) subgroups, where the CSZ sub group was subdivided by antipsychotic treatment. In order to measure the potential neuronal damage, plasma levels of β-III tubulin, neurofilament light chain (Nf-L), and glial fibrillary acidic protein (GFAP) were performed. The results revealed that the levels of these proteins were increased in the SZ group compared to the control group (P < 0.05). Moreover, multiple comparison analysis showed highly significant levels of β-III tubulin (P = 0.0002), Nf-L (P = 0.0403) and GFAP (P < 0.015) in the subgroup of CSZ clozapine-treated. In conclusion, β-III tubulin, Nf-L and GFAP proteins may be potential biomarkers of neurodegeneration and progression in SZen
dc.description.sponsorshipFundação para a Ciência e a Tecnologia | Ref. SFRH/BD/135623/20spa
dc.description.sponsorshipInstituto de Salud Carlos III | Ref. P16/00405spa
dc.description.sponsorshipMinisterio de Sanidad, Igualdad y Política Social | Ref. 2017I054spa
dc.description.sponsorshipAgencia del Conocimiento en Salud | Ref. PRIS2-17spa
dc.description.sponsorshipXunta de Galicia | Ref. IN607C-2017/02spa
dc.description.sponsorshipXunta de Galicia | Ref. IN607B 2018/17spa
dc.language.isoengspa
dc.publisherScientific Reportsspa
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePlasma β-III tubulin, neurofilament light chain and glial fibrillary acidic protein are associated with neurodegeneration and progression in schizophreniaen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.1038/s41598-020-71060-4
dc.identifier.editorhttps://www.nature.com/articles/s41598-020-71060-4spa
dc.publisher.departamentoQuímica Físicaspa
dc.publisher.departamentoComunicación audiovisual e publicidadespa
dc.publisher.departamentoDpto. Externospa
dc.publisher.grupoinvestigacionTEAM NANO TECH (Grupo de Nanotecnoloxía)spa
dc.subject.unesco3211 Psiquiatríaspa
dc.subject.unesco3208 Farmacodinámicaspa
dc.subject.unesco6106.07 Procesos Mentalesspa
dc.date.updated2022-10-06T08:07:52Z
dc.computerCitationpub_title=Scientific Reports|volume=10|journal_number=1|start_pag=14271|end_pag=spa


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    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International