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dc.contributor.authorPérez Davila, Sara 
dc.contributor.authorGonzález Rodríguez, Laura 
dc.contributor.authorLama, Raquel
dc.contributor.authorLópez Álvarez, Miriam 
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorSerra Rodríguez, Julia Asunción 
dc.contributor.authorNovoa, Beatriz
dc.contributor.authorFigueras, Antonio
dc.contributor.authorGonzález Fernández, Pío Manuel 
dc.date.accessioned2022-10-17T10:33:25Z
dc.date.available2022-10-17T10:33:25Z
dc.date.issued2022-10-01
dc.identifier.citationPolymers, 14(19): 4117 (2022)spa
dc.identifier.issn20734360
dc.identifier.urihttp://hdl.handle.net/11093/3951
dc.descriptionFinanciado para publicación en acceso aberto: Universidade de Vigo/CISUG
dc.description.abstractPolylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered.en
dc.description.sponsorshipPOCTEP INTERREG España- Portugal | Ref. BLUEBIOLABspa
dc.description.sponsorshipInterreg Atlantic Area | Ref. BLUEHUMAN EAPA_151/2016spa
dc.description.sponsorshipMinisterio de Ciencia e Innovación | Ref. PID 2020-115415RB-100spa
dc.description.sponsorshipXunta de Galicia | Ref. ED431C 2021/49spa
dc.description.sponsorshipXunta de Galicia | Ref. ED481A 2019/314spa
dc.description.sponsorshipXunta de Galicia | Ref. IN606A-2017/011spa
dc.description.sponsorshipFundação para a Ciência e a Tecnologia | Ref. UIDB/50016/2020spa
dc.language.isoengspa
dc.publisherPolymersspa
dc.relationinfo:eu-repo/grantAgreement/MICINN//PID2020-115415RB-100/ES
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title3D-printed PLA medical devices: physicochemical changes and biological response after sterilisation treatmentsen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/polym14194117
dc.identifier.editorhttps://www.mdpi.com/2073-4360/14/19/4117spa
dc.publisher.departamentoFísica aplicadaspa
dc.publisher.grupoinvestigacionNovos Materiaisspa
dc.subject.unesco2206.10 Polímerosspa
dc.subject.unesco3314 Tecnología Médicaspa
dc.subject.unesco2210 Química Físicaspa
dc.date.updated2022-10-17T10:27:29Z
dc.computerCitationpub_title=Polymers|volume=14|journal_number=19|start_pag=4117|end_pag=spa


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    Attribution 4.0 International
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