Marine macrolides to tackle antimicrobial resistance of mycobacterium tuberculosis
UNIVERSAL IDENTIFIER: http://hdl.handle.net/11093/4001
EDITED VERSION: https://www.mdpi.com/1660-3397/20/11/691
UNESCO SUBJECT: 3205.05 Enfermedades Infecciosas ; 2414 Microbiología ; 3201.03 Microbiología Clínica
DOCUMENT TYPE: article
Tuberculosis has become a major health problem globally. This is worsened by the emergence of resistant strains of Mycobacterium tuberculosis showing ability to evade the effectiveness of the current antimycobacterial therapies. Therefore, the efforts carried out to explore new entities from many sources, including marine, are critical. This review summarizes several marine-derived macrolides that show promising activity against M. tuberculosis. We also provide information regarding the biosynthetic processes of marine macrolides, including the challenges that are usually experienced in this process. As most of the studies reporting the antimycobacterial activities of the listed marine macrolides are based on in vitro studies, the future direction should consider expanding the trials to in vivo and clinical trials. In addition, in silico studies should also be explored for a quick screening on marine macrolides with potent activities against mycobacterial infection. To sum up, macrolides derived from marine organisms might become therapeutical options for tackling antimycobacterial resistance of M. tuberculosis.
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