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dc.contributor.authorHenriques, Sílvia F.
dc.contributor.authorDuque, Pedro
dc.contributor.authorLópez Fernández, Hugo 
dc.contributor.authorVázquez, Noé
dc.contributor.authorFernández Riverola, Florentino 
dc.contributor.authorReboiro Jato, Miguel 
dc.contributor.authorVieira, Cristina P.
dc.contributor.authorVieira, Jorge
dc.date.accessioned2022-11-25T13:18:54Z
dc.date.available2022-11-25T13:18:54Z
dc.date.issued2019-06-18
dc.identifier.citationBMC Evolutionary Biology, 19(1): 126 (2019)spa
dc.identifier.issn14712148
dc.identifier.urihttp://hdl.handle.net/11093/4153
dc.description.abstractBackground: L-ascorbate (Vitamin C) is an important antioxidant and co-factor in eukaryotic cells, and in mammals it is indispensable for brain development and cognitive function. Vertebrates usually become L-ascorbate auxothrophs when the last enzyme of the synthetic pathway, an L-gulonolactone oxidase (GULO), is lost. Since Protostomes were until recently thought not to have a GULO gene, they were considered to be auxothrophs for Vitamin C. Results: By performing phylogenetic analyses with tens of non-Bilateria and Protostomian genomes, it is shown, that a GULO gene is present in the non-Bilateria Placozoa, Myxozoa (here reported for the first time) and Anthozoa groups, and in Protostomians, in the Araneae family, the Gastropoda class, the Acari subclass (here reported for the first time), and the Priapulida, Annelida (here reported for the first time) and Brachiopoda phyla lineages. GULO is an old gene that predates the separation of Animals and Fungi, although it could be much older. We also show that within Protostomes, GULO has been lost multiple times in large taxonomic groups, namely the Pancrustacea, Nematoda, Platyhelminthes and Bivalvia groups, a pattern similar to that reported for Vertebrate species. Nevertheless, we show that Drosophila melanogaster seems to be capable of synthesizing L-ascorbate, likely through an alternative pathway, as recently reported for Caenorhabditis elegans. Conclusions: Non-Bilaterian and Protostomians seem to be able to synthesize Vitamin C either through the conventional animal pathway or an alternative pathway, but in this animal group, not being able to synthesize L-ascorbate seems to be the exception rather than the ruleen
dc.description.sponsorshipXunta de Galicia | Ref. ED431C2018/55-GRCspa
dc.description.sponsorshipNorte 2020 y FEDER | Ref. Norte-01-0145-FEDER-000008spa
dc.description.sponsorshipXunta de Galicia | Ref. ED481B 2016/068–0spa
dc.language.isoengspa
dc.publisherBMC Evolutionary Biologyspa
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMultiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal speciesen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.1186/s12862-019-1454-8
dc.identifier.editorhttps://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-019-1454-8spa
dc.publisher.departamentoInformáticaspa
dc.publisher.grupoinvestigacionSistemas Informáticos de Nova Xeraciónspa
dc.subject.unesco2302 Bioquímicaspa
dc.subject.unesco2302.21 Biología Molecularspa
dc.date.updated2022-11-25T13:14:34Z
dc.computerCitationpub_title=BMC Evolutionary Biology|volume=19|journal_number=1|start_pag=126|end_pag=spa
dc.referencesSING group thanks the CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure.spa


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    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International