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dc.contributor.authorCalo Rodríguez, Jessica 
dc.contributor.authorComesaña Fernández, Sara 
dc.contributor.authorAlonso Gómez, Ángel
dc.contributor.authorSoengas Fernández, José Luis 
dc.contributor.authorBlanco Imperiali, Ayelén Melisa 
dc.date.accessioned2023-03-30T10:45:31Z
dc.date.available2023-03-30T10:45:31Z
dc.date.issued2023-02-21
dc.identifier.citationInternational Journal of Molecular Sciences, 24(5): 4275 (2023)spa
dc.identifier.issn14220067
dc.identifier.urihttp://hdl.handle.net/11093/4668
dc.description.abstractIt is well established in mammals that the gastrointestinal tract (GIT) senses the luminal presence of nutrients and responds to such information by releasing signaling molecules that ultimately regulate feeding. However, gut nutrient sensing mechanisms are poorly known in fish. This research characterized fatty acid (FA) sensing mechanisms in the GIT of a fish species with great interest in aquaculture: the rainbow trout (Oncorhynchus mykiss). Main results showed that: (i) the trout GIT has mRNAs encoding numerous key FA transporters characterized in mammals (FA transporter CD36 -FAT/CD36-, FA transport protein 4 -FATP4-, and monocarboxylate transporter isoform-1 -MCT-1-) and receptors (several free FA receptor -Ffar- isoforms, and G protein-coupled receptors 84 and 119 -Gpr84 and Gpr119-), and (ii) intragastrically-administered FAs differing in their length and degree of unsaturation (i.e., medium-chain (octanoate), long-chain (oleate), long-chain polyunsaturated (α-linolenate), and short-chain (butyrate) FAs) exert a differential modulation of the gastrointestinal abundance of mRNAs encoding the identified transporters and receptors and intracellular signaling elements, as well as gastrointestinal appetite-regulatory hormone mRNAs and proteins. Together, results from this study offer the first set of evidence supporting the existence of FA sensing mechanisms n the fish GIT. Additionally, we detected several differences in FA sensing mechanisms of rainbow trout vs. mammals, which may suggest evolutionary divergence between fish and mammals.en
dc.description.sponsorshipXunta de Galicia | Ref. ED431B 2022/01spa
dc.description.sponsorshipAgencia Estatal de Investigación española | Ref. PID2019-103969RB-C31spa
dc.description.sponsorshipMinisterio de Educación, Cultura y Deporte | Ref. FPU19/00122spa
dc.description.sponsorshipMinisterio de Educación, Cultura y Deporte | Ref. FPU16/00045spa
dc.description.sponsorshipMinisterio de Ciencia e Innovación | Ref. IJC2019-039166-Ispa
dc.language.isoengspa
dc.publisherInternational Journal of Molecular Sciencesspa
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103969RB-C31/ES
dc.relationinfo:eu-repo/grantAgreement/MECD//FPU16-00045/ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJC2019-039166-I/ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FPU19/00122/ES
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleFatty acid sensing in the gastrointestinal tract of rainbow trout: different to mammalian model?en
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/ijms24054275
dc.identifier.editorhttps://www.mdpi.com/1422-0067/24/5/4275spa
dc.publisher.departamentoBioloxía funcional e ciencias da saúdespa
dc.publisher.grupoinvestigacionFisioloxía de Peixesspa
dc.subject.unesco2401.13 Fisiología Animalspa
dc.subject.unesco3105.07 Hábitos de Alimentaciónspa
dc.subject.unesco3105 Peces y Fauna Silvestrespa
dc.date.updated2023-03-30T10:40:10Z
dc.computerCitationpub_title=International Journal of Molecular Sciences|volume=24|journal_number=5|start_pag=4275|end_pag=spa


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