Show simple item record

dc.contributor.authorFreiría Martínez, Luis
dc.contributor.authorIglesias Martínez Almeida, Marta
dc.contributor.authorRodríguez Jamardo, Cynthia
dc.contributor.authorRivera Baltanás, Tania
dc.contributor.authorComís Tuche, María
dc.contributor.authorRodrigues Amorim, Daniela
dc.contributor.authorFernández Palleiro, Patricia
dc.contributor.authorBlanco Formoso, María 
dc.contributor.authorDiz Chaves, Yolanda Maria 
dc.contributor.authorGonzález Freiria, Natalia
dc.contributor.authorSuárez Albo, María
dc.contributor.authorMartín Forero Maestre, Montserrat
dc.contributor.authorDurán Fernández-Feijoo, Cristina
dc.contributor.authorFernández Lorenzo, Jose Ramón
dc.contributor.authorConcheiro Guisán, Ana
dc.contributor.authorOlivares, José Manuel
dc.contributor.authorSpuch Calvar, Carlos 
dc.date.accessioned2023-08-30T10:04:07Z
dc.date.available2023-08-30T10:04:07Z
dc.date.issued2023-07-24
dc.identifier.citationNutrients, 15(14): 3284 (2023)spa
dc.identifier.issn20726643
dc.identifier.urihttp://hdl.handle.net/11093/5098
dc.description.abstractHuman milk is the biological fluid with the highest exosome amount and is rich in microRNAs (miRNAs). These are key regulators of gene expression networks in both normal physiologic and disease contexts, miRNAs can influence many biological processes and have also shown promise as biomarkers for disease. One of the key aspects in the regeneration of the nervous system is that there are practically no molecules that can be used as potential drugs. In the first weeks of lactation, we know that human breast milk must contain the mechanisms to transmit molecular and biological information for brain development. For this reason, our objective is to identify new modulators of the nervous system that can be used to investigate neurodevelopmental functions based on miRNAs. To do this, we collected human breast milk samples according to the time of delivery and milk states: mature milk and colostrum at term; moderate and very preterm mature milk and colostrum; and late preterm mature milk. We extracted exosomes and miRNAs and realized the miRNA functional assays and target prediction. Our results demonstrate that miRNAs are abundant in human milk and likely play significant roles in neurodevelopment and normal function. We found 132 different miRNAs were identified across all samples. Sixty-nine miRNAs had significant differential expression after paired group comparison. These miRNAs are implicated in gene regulation of dopaminergic/glutamatergic synapses and neurotransmitter secretion and are related to the biological process that regulates neuron projection morphogenesis and synaptic vesicle transport. We observed differences according to the delivery time and with less clarity according to the milk type. Our data demonstrate that miRNAs are abundant in human milk and likely play significant roles in neurodevelopment and normal function.en
dc.description.sponsorshipSociedad de Pediatría Gallega | Ref. BecaSOPEGA2016spa
dc.description.sponsorshipAxencia Galega de Innovación | Ref. IN607B-2018/17spa
dc.description.sponsorshipAxencia Galega de Innovación | Ref. PI20/00937spa
dc.description.sponsorshipAxencia Galega de Innovación | Ref. IN606A-2019/022spa
dc.language.isoengspa
dc.publisherNutrientsspa
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHuman breast milk microRNAs, potential players in the regulation of nervous systemen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/nu15143284
dc.identifier.editorhttps://www.mdpi.com/2072-6643/15/14/3284spa
dc.publisher.departamentoQuímica Físicaspa
dc.publisher.departamentoBioquímica, xenética e inmunoloxíaspa
dc.publisher.grupoinvestigacionTEAM NANO TECH (Grupo de Nanotecnoloxía)spa
dc.publisher.grupoinvestigacionFisioloxía Endocrina e Neurofisioloxíaspa
dc.subject.unesco3205.07 Neurologíaspa
dc.subject.unesco2411.11 Neurofisiologíaspa
dc.subject.unesco2302 Bioquímicaspa
dc.date.updated2023-08-30T09:52:05Z
dc.computerCitationpub_title=Nutrients|volume=15|journal_number=14|start_pag=3284|end_pag=spa


Files in this item

[PDF]

    Show simple item record

    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International