RT Journal Article
T1 Hydrothermal processing of Laminaria ochroleuca for the production of crude extracts used to formulate polymeric nanoparticles
A1 Flórez Fernández, Noelia
A1 Alvarez Viñas, Milena
A1 Guerreiro, Filipa
A1 Torres Pérez, María Dolores
A1 Grenha, Ana Margarida Moutinho
A1 Domínguez González, Herminia
K1 2510.04 Botánica Marina
K1 3209.90 Farmacología Experimental
K1 3328.25 Extracción Sólido - Líquido
AB A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈250–350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery.
PB Marine Drugs
SN 16603397
YR 2020
FD 2020-06-27
LK http://hdl.handle.net/11093/1749
UL http://hdl.handle.net/11093/1749
LA eng
NO Marine Drugs, 18(7): 336 (2020)
NO Portuguese Foundation for Science and Technology | Ref. UID/Multi/04326/2019
DS Investigo
RD 05-oct-2024