RT Journal Article
T1 Epitope-based immunoinformatics approach on nucleocapsid protein of severe acute respiratory syndrome-Coronavirus-2
A1 Rakib, Ahmed
A1 Sami, Saad Ahmed
A1 Islam, Md. Ashiqul
A1 Ahmed, Shahriar
A1 Faiz, Farhana Binta
A1 Khanam, Bibi Humayra
A1 Marma, Kay Kay Shain
A1 Rahman, Maksuda
A1 Uddin, Mir Muhammad Nasir
A1 Nainu, Firzan
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 2420.08 Virus Respiratorios
K1 2412.06 Inmunización
K1 3202 Epidemiología
AB With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) has announced the infectious disease caused by SARS-CoV-2, which is known as coronavirus disease-2019 (COVID-2019), as a global pandemic. Additionally, the positive cases are still following an upward trend worldwide and as a corollary, there is a need for a potential vaccine to impede the progression of the disease. Lately, it has been documented that the nucleocapsid (N) protein of SARS-CoV-2 is responsible for viral replication and interferes with host immune responses. We comparatively analyzed the sequences of N protein of SARS-CoV-2 for the identification of core attributes and analyzed the ancestry through phylogenetic analysis. Subsequently, we predicted the most immunogenic epitope for the T-cell and B-cell. Importantly, our investigation mainly focused on major histocompatibility complex (MHC) class I potential peptides and NTASWFTAL interacted with most human leukocyte antigen (HLA) that are encoded by MHC class I molecules. Further, molecular docking analysis unveiled that NTASWFTAL possessed a greater affinity towards HLA and also available in a greater range of the population. Our study provides a consolidated base for vaccine design and we hope that this computational analysis will pave the way for designing novel vaccine candidates.
PB Molecules
SN 14203049
YR 2020
FD 2020-11-02
LK http://hdl.handle.net/11093/1781
UL http://hdl.handle.net/11093/1781
LA eng
NO Molecules, 25(21): 5088 (2020)
DS Investigo
RD 13-oct-2024