RT Journal Article
T1 Insightful valorization of the biological activities of Pani Heloch leaves through experimental and computer-aided mechanisms
A1 Banu, Naureen
A1 Alam, Najmul
A1 Islam, Mohammad Nazmul
A1 Islam, Sanjida
A1 Sakib, Shahenur Alam
A1 Hanif, Nujhat Binte
A1 Chowdhury, Md. Riad
A1 Tareq, Abu Montakim
A1 Chowdhury, Kamrul Hasan
A1 Jahan, Shamima
A1 Azad, Afrina
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 3209.07 Fitofármacos
K1 3209.04 Medicamentos Naturales
K1 3309.03 Antioxidantes en Los Alimentos
AB Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant, anti-inflammatory, and thrombolytic effects; and in vivo antipyretic and analgesic properties of the methanol extract of A. montanum leaves in different experimental models. The extract exhibited secondary metabolites including alkaloids, flavonoids, flavanols, phytosterols, cholesterols, phenols, terpenoids, glycosides, fixed oils, emodines, coumarins, resins, and tannins. Besides, Pani heloch showed strong antioxidant activity (IC50 = 99.00 µg/mL), while a moderate percentage of clot lysis (31.56%) in human blood and significant anti-inflammatory activity (p < 0.001) was achieved with the standard. Moreover, the analgesic and antipyretic properties appeared to trigger a significant response (p < 0.001) relative to in the control group. Besides, an in silico study of carpusin revealed favorable protein-binding affinities. Furthermore, the absorption, distribution, metabolism, excretion, and toxicity analysis and toxicological properties of all isolated compounds adopted Lipinski’s rule of five for drug-like potential and level of toxicity. Our research unveiled that the methanol extract of A. montanum leaves exhibited secondary metabolites that are a good source for managing inflammation, pyrexia, pain, and cellular toxicity. Computational approaches and further studies are required to identify the possible mechanism which responsible for the biological effects.
PB Molecules
SN 14203049
YR 2020
FD 2020-11-05
LK http://hdl.handle.net/11093/1876
UL http://hdl.handle.net/11093/1876
LA eng
NO Molecules, 25(21): 5153 (2020)
DS Investigo
RD 30-sep-2023