RT Journal Article
T1 Antioxidant-rich Woodfordia fruticosa leaf extract alleviates depressive-like behaviors and impede hyperglycemia
A1 Tayab, Mohammed Abu
A1 Chowdhury, Kazi Ashfak Ahmed
A1 Jabed, Md.
A1 Tareq, Syed Mohammed
A1 Kamal, A. T. M. Mostafa
A1 Islam, Mohammad Nazmul
A1 Uddin, A. M. Kafil
A1 Hossain, Mohammad Adil
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 3209.04 Medicamentos Naturales
K1 2302.21 Biología Molecular
K1 3309.03 Antioxidantes en Los Alimentos
AB Dhaiphul (Woodfordia fruticosa) is a frequently demanded plant in South-East Asian regions for its diverse medicinal values. This study was proposed to examine antioxidant, antidiabetic, and antidepressant potentials of methanol extract of W. fruticosa leaves (MEWF) and its derived n-hexane (NHFMEWF) and ethyl acetate (EAFMEWF) fractions through in vitro, in vivo, and computational models. Among test samples, MEWF and EAFMEWF contained the highest phenolic content and showed maximal antioxidant activity in DPPH radical scavenging and ferric reducing power assays. In comparison, NHFMEWF possessed maximum flavonoid content and a significantly potent α-amylase inhibitory profile comparable with positive control acarbose. In animal models of depression (forced swimming and tail suspension test), EAFMEWF and NHFMEWF demonstrated a dose-dependent antidepressant-like effect; explicitly, the depressive-like behaviors significantly declined in EAFMEWF-treated dosing groups in contrast to the control group. In the computational analysis, previously isolated flavonoid compounds from Dhaiphul leaves manifested potent binding affinity against several key therapeutic target proteins of diabetes and depressive disorders including α-amylase, serotonin transporter, dopamine transporter, and neuronal nitric oxide synthase with varying pharmacokinetics and toxicity profiles. This research’s outcomes may provide potential dietary supplements for mitigating hyperglycemia, cellular toxicity, and depressive disorder.
PB Plants
SN 22237747
YR 2021
FD 2021-02-03
LK http://hdl.handle.net/11093/1957
UL http://hdl.handle.net/11093/1957
LA eng
NO Plants, 10(2): 287 (2021)
DS Investigo
RD 20-sep-2024