RT Journal Article
T1 Heart histopathology and mitochondrial ultrastructure in aged rats fed for 24 months on different unsaturated fats (virgin olive oil, sunflower oil or fish oil) and affected by different longevity
A1 Navarro Hortal, María Dolores
A1 Ramírez Tortosa, César
A1 Varela López, Alfonso
A1 Romero Márquez, José M.
A1 Ochoa, Julio
A1 Ramírez Tortosa, M. Carmen
A1 Forbes Hernández, Tamara Yuliett
A1 Granados Principal, Sergio
A1 Battino , Maurizio
A1 Quiles Morales, José Luis
K1 2301 Química Analítica
K1 3206 Ciencias de la Nutrición
K1 3309.20 Propiedades de Los Alimentos
AB Diet plays a decisive role in heart physiology, with lipids having especial importance in pathology prevention and development. This study aimed to investigate how dietary lipids varying in lipid profile (virgin olive oil, sunflower oil or fish oil) affected the heart of rats during aging. Heart histopathology, mitochondrial morphometry, and oxidative status were assessed. Typical histopathological features associated with aging, such as valvular lesions, endomyocardical hyperplasia, or papillary muscle calcification, were found at a low extent in all the experimental groups. The most relevant finding was that inflammation registered by fish oil group was lower compared to the other treatments. At the ultrastructural level, heart mitochondrial area, perimeter, and aspect ratio were higher in fish oil-fed rats than in those fed on sunflower oil. Concerning oxidative stress markers, there were differences only in coenzyme Q levels and catalase activity, lower in sunflower oil-fed animals compared with those fed on fish oil. In summary, dietary intake for a long period on dietary fats with different fatty acids profile led to differences in some aspects associated with the aging process at the heart. Fish oil seems to be the fat most protective of heart during aging.
PB Nutrients
SN 20726643
YR 2019
FD 2019-10-07
LK http://hdl.handle.net/11093/2053
UL http://hdl.handle.net/11093/2053
LA eng
NO Nutrients, 11(10): 2390 (2019)
NO Ministerio de Educación y Ciencia (España) | Ref. AGL2008-01057
DS Investigo
RD 01-dic-2023