RT Journal Article
T1 Plant-based indole alkaloids: a comprehensive overview from a pharmacological perspective
A1 Omar, Faisal
A1 Tareq, Abu Montakim
A1 Alqahtani, Ali M.
A1 Dhama, Kuldeep
A1 Sayeed, Mohammed Abu
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 2302.01 Alcaloides
K1 3209.07 Fitofármacos
K1 3209.03 Evaluación de Medicamentos
AB Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads.
PB Molecules
SN 14203049
YR 2021
FD 2021-04-15
LK http://hdl.handle.net/11093/2123
UL http://hdl.handle.net/11093/2123
LA eng
NO Molecules, 26(8): 2297 (2021)
DS Investigo
RD 30-sep-2023