RT Journal Article
T1 Contribution of K2P potassium channels to cardiac physiology and pathophysiology
A1 Herrera Pérez, Salvador
A1 Campos Ríos, Ana
A1 Rueda Ruzafa, Lola
A1 Lamas Castro, José Antonio
K1 3207.04 Patología Cardiovascular
K1 3205.01 Cardiología
K1 2411.03 Fisiología Cardiovascular
AB Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome.
PB International Journal of Molecular Sciences
SN 14220067
YR 2021
FD 2021-06-21
LK http://hdl.handle.net/11093/2531
UL http://hdl.handle.net/11093/2531
LA eng
NO International Journal of Molecular Sciences, 22(12): 6635 (2021)
NO Agencia Estatal de Investigación | Ref. PID2019-109425GB-I00
DS Investigo
RD 11-dic-2024