RT Journal Article
T1 An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes
A1 Monikh, Fazel Abdolahpur
A1 Chupani, Latifeh
A1 Karkossa, Isabel
A1 Gardian, Zdenko
A1 Arenas Lago, Daniel
A1 von Bergen, Martin
A1 Schubert, Kristin
A1 Piackova, Veronika
A1 Zuskova, Eliska
A1 Jiskoot, Wim
A1 Vijver, Martina G.
A1 Peijnenburg, Willie J.G.M.
K1 3105 Peces y Fauna Silvestre
K1 2415 Biología Molecular
K1 2401 Biología Animal (Zoología)
AB Nanomaterials (NMs) taken up from the environment carry a complex ecocorona consisting of dissolved organic matter. An ecocorona is assumed to influence the interactions between NMs and endogenous biomolecules and consequently affects the formation of a biological corona (biocorona) and the biological fate of the NMs. This study shows that biomolecules in fish plasma attach immediately (within <5 min) to the surface of SWCNTs and the evolution of the biocorona is a size dependent phenomenon. Quantitative proteomics data revealed that the nanotube size also influences the plasma protein composition on the surface of SWCNTs. The presence of a pre-attached ecocorona on the surface of SWCNTs eliminated the influence of nanotube size on the formation and evolution of the biocorona. Over time, endogenous biomolecules from the plasma partially replaced the pre-attached ecocorona as measured using a fluorescently labelled ecocorona. The presence of an ecocorona offers a unique surface composition to each nanotube. This suggests that understanding the biological fate of NMs taken up from the environment by organisms to support the environmental risk assessment of NMs is a challenging task because each NM may have a unique surface composition in the body of an organism.
PB NanoImpact
SN 24520748
YR 2021
FD 2021-04
LK http://hdl.handle.net/11093/2740
UL http://hdl.handle.net/11093/2740
LA eng
NO NanoImpact, 22, 100315 (2021)
NO European Commission | Ref. BTBnano H2020-MSCA-IF n. 793936
DS Investigo
RD 09-oct-2024