RT Journal Article
T1 A systematic review of biosynthesized metallic nanoparticles as a promising anti-cancer-strategy
A1 Andleeb, Anisa
A1 Andleeb, Aneeta
A1 Asghar, Salman
A1 Zaman, Gouhar
A1 Tariq, Muhammad
A1 Mehmood, Azra
A1 Nadeem, Muhammad
A1 Hano, Christophe
A1 Lorenzo Rodríguez, José Manuel
A1 Abbasi, Bilal Haider
K1 3207.03 Carcinogénesis
K1 3208.06 Quimioterapia
K1 3209.90 Farmacología Experimental
AB Cancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus far; however, conventional chemotherapeutic drugs have lower bioavailability, rapid renal clearance, unequal delivery, and severe side effects. In the recent years, nanotechnology has flourished rapidly and has a multitude of applications in the biomedical field. Bio-mediated nanoparticles (NPs) are cost effective, safe, and biocompatible and have got substantial attention from researchers around the globe. Due to their safe profile and fewer side effects, these nanoscale materials offer a promising cure for cancer. Currently, various metallic NPs have been designed to cure or diagnose cancer; among these, silver (Ag), gold (Au), zinc (Zn) and copper (Cu) are the leading anti-cancer NPs. The anticancer potential of these NPs is attributed to the production of reactive oxygen species (ROS) in cellular compartments that eventually leads to activation of autophagic, apoptotic and necrotic death pathways. In this review, we summarized the recent advancements in the biosynthesis of Ag, Au, Zn and Cu NPs with emphasis on their mechanism of action. Moreover, nanotoxicity, as well as the future prospects and opportunities of nano-therapeutics, are also highlighted.
PB Cancers
SN 20726694
YR 2021
FD 2021-06-05
LK http://hdl.handle.net/11093/2767
UL http://hdl.handle.net/11093/2767
LA eng
NO Cancers, 13(11): 2818 (2021)
DS Investigo
RD 09-oct-2024