RT Journal Article
T1 Immunomodulatory and antitumoral activity of gold nanoparticles synthesized by red algae aqueous extracts
A1 González Ballesteros, Noelia
A1 Diego González, Lara
A1 Lastra Valdor, Mariano De La
A1 Grimaldi, Maria
A1 Cavazza, Antonella
A1 Bigi, Franca
A1 Rodríguez Argüelles, Maria Carmen
A1 Simón Vázquez, Rosana
K1 2412 Inmunología
K1 2417.07 Algología (Ficología)
K1 2302 Bioquímica
AB This study reports on the green and cost-efficient synthesis of gold nanoparticles from three different red algae extracts. The nanoparticles synthesized were fully characterized by UV-Vis spectroscopy, HRTEM, and Z-potential. Relevant components occurring in the extracts, such as polysaccharides or phenolic content, were assessed by analytical techniques such as spectrophotometric assays and liquid chromatography. Finally, the antioxidant, antitumoral, and anti-inflammatory potential of both the extracts and the gold nanoparticles synthesized were analyzed in order to determine a possible synergistic effect on the nanoparticles. The results obtained confirmed the obtainment of gold nanoparticles with significant potential as immunotherapeutic agents. The therapeutic potential of these nanoparticles could be higher than that of inert gold nanoparticles loaded with bioactive molecules since the former would allow for higher accumulation into the targeted tissue.
PB Marine Drugs
SN 16603397
YR 2022
FD 2022-02-28
LK http://hdl.handle.net/11093/3201
UL http://hdl.handle.net/11093/3201
LA eng
NO Marine Drugs, 20(3): 182 (2022)
NO Xunta de Galicia | Ref. ED431C 2018/54-GRC.
DS Investigo
RD 01-dic-2023