RT Journal Article
T1 Multiregional tumor trees are not phylogenies
A1 Fernandes Alves, Joao Miguel
A1 Prieto Fernandez, Tamara
A1 Posada González, David
K1 2409 Genética
K1 2409.03 Genética de Poblaciones
AB Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees built from bulk mutational profiles do not consider this heterogeneity and can potentially lead to erroneous evolutionary inferences, including biased timing of somatic mutations, spurious parallel mutation events, and/or incorrect chronological ordering of metastatic events.
PB Trends in Cancer
SN 24058033
YR 2017
FD 2017-08
LK http://hdl.handle.net/11093/3408
UL http://hdl.handle.net/11093/3408
LA eng
NO Trends in Cancer, 3(8): 546-550 (2017)
DS Investigo
RD 14-sep-2024