RT Journal Article
T1 Consequences of substitution model selection on protein ancestral sequence reconstruction
A1 Del Amparo Temporao, Roberto
A1 Arenas Busto, Miguel
K1 2409.03 Genética de Poblaciones
AB The selection of the best-fitting substitution model of molecular evolution is a traditional step for phylogenetic inferences, including ancestral sequence reconstruction (ASR). However, a few recent studies suggested that applying this procedure does not affect the accuracy of phylogenetic tree reconstruction. Here, we revisited this debate topic by analyzing the influence of selection among substitution models of protein evolution, with focus on exchangeability matrices, on the accuracy of ASR using simulated and real data. We found that the selected best-fitting substitution model produces the most accurate ancestral sequences, especially if the data present large genetic diversity. Indeed, ancestral sequences reconstructed under substitution models with similar exchangeability matrices were similar, suggesting that if the selected best-fitting model cannot be used for the reconstruction, applying a model similar to the selected one is preferred. We conclude that selecting among substitution models of protein evolution is recommended for reconstructing accurate ancestral sequences.
PB Molecular Biology and Evolution
SN 07374038
YR 2022
FD 2022-07
LK http://hdl.handle.net/11093/3778
UL http://hdl.handle.net/11093/3778
LA eng
NO Molecular Biology and Evolution, 39(7): msac144 (2022)
NO Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG
NO Agencia Estatal de Investigación | Ref. PID2019-107931GA-I00
DS Investigo
RD 09-sep-2024