RT Journal Article
T1 Role of voltage-sensitive Ca2+ channels in the in vivo dopamine release induced by the organophosphorus pesticide glufosinate ammonium in rat striatum
A1 Costas Ferreira, María Del Carmen
A1 Romero Rodríguez, Társila
A1 Duran Barbosa, Rafael
A1 Ferreira Faro, Lilian Rosana
K1 3205.07 Neurología
K1 2411.11 Neurofisiología
K1 2490 Neurociencias
AB The possible role of voltage-sensitive calcium channels (VSCC) activation in the glufosinate ammonium (GLA)-induced dopamine release was investigated using selective VSCC blockers and the dopamine levels weremeasured by HPLC from samples obtained by in vivo cerebral microdialysis. While pretreatment with 10 μMflunarizine (T-type VSCC antagonist) or nicardipine (L-type VSCC antagonist) had no statistically significanteffect on dopamine release induced by 10 mM GLA, pretreatment with 100 μM of both antagonists, or 20 μMω-conotoxin MVIIC (non-selective P/Q-type VSCC antagonist) significantly decreased the GLA-induced dopaminerelease over 72.2%, 73%, and 70.2%, respectively. Administration of the specific antagonist of neuronal N-typeVSCCs, the ω-conotoxin GVIA (20 μM), produced an almost complete blockade of in vivo dopamine releaseinduced by GLA. These results show that GLA-induced dopamine release could be produced by the activation of awide range of striatal VSCC located at the synaptic terminals and axons of striatal dopaminergic neurons,especially N-type VSCC.
PB Toxicology Letters
SN 03784274
YR 2023
FD 2023-01
LK http://hdl.handle.net/11093/4190
UL http://hdl.handle.net/11093/4190
LA eng
NO Toxicology Letters, 373, 105-113 (2023)
NO Financiaciado para publicación en acceso aberto: Universidade de Vigo/CISUG
NO Xunta de Galicia | Ref. ED431B2019/33
DS Investigo
RD 15-sep-2024