RT Journal Article
T1 Gold nanoparticles synthesized by an aqueous extract of Codium tomentosum as potential antitumoral enhancers of gemcitabine
A1 González Ballesteros, Noelia
A1 Maietta , Immacolata
A1 Rey Méndez, Raquel
A1 Rodríguez Argüelles, Maria Carmen
A1 Lastra Valdor, Mariano De La
A1 Cavazza, Antonella
A1 Grimaldi, Maria
A1 Bigi, Franca
A1 Simón Vázquez, Rosana
K1 3207.03 Carcinogénesis
K1 2412 Inmunología
K1 2390 Química Farmacéutica
AB Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a Codium tomentosum (CT) aqueous extract was employed for the green synthesis of gold nanoparticles (Au@CT). The complete characterization of Au@CT was performed by UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Zeta potential, electron microscopy, X-ray powder diffraction (XRD), high-performance steric exclusion chromatography (HPSEC), and by the determination of their antioxidant capacity. The antiproliferative activity of Au@CT was then tested in hepatic (HEPG-2) and pancreatic (BxPC-3) cell lines. Their potential capacity as enhancers of gemcitabine, a drug frequently used to treat both types of tumors, was also tested. The activity of Au@CT was compared to the activity of the CT extract alone. A synergistic effect with gemcitabine was proven for HEPG-2. Our results showed that gold nanoparticles synthesized from seaweed extracts with antitumoral activity could be a good gemcitabine enhancer.
PB Marine Drugs
SN 16603397
YR 2022
FD 2022-12-27
LK http://hdl.handle.net/11093/4313
UL http://hdl.handle.net/11093/4313
LA eng
NO Marine Drugs, 21(1): 20 (2023)
NO Xunta de Galicia | Ref. ED431C 2022/26
DS Investigo
RD 08-sep-2024