RT Journal Article
T1 Nanostructured heterogeneous catalysts for bioorthogonal reactions
A1 Sousa Castillo, Ana
A1 Mariño Lopez, Andrea
A1 Puertolas Lacambra, Begoña
A1 Correa Duarte, Miguel Ángel
K1 3303 Ingeniería y Tecnología Químicas
K1 2302 Bioquímica
K1 2307 Química Física
AB Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems. Following the premise that they do not interfere with biological functions, bioorthogonal reactions are increasingly applied in biomedical research, particularly with respect to genetic encoding systems, fluorogenic reactions for bioimaging, and cancer therapy. This Minireview compiles recent advances in the use of heterogeneous catalysts for bioorthogonal reactions. The synthetic strategies of Pd-, Au-, and Cu-based materials, their applicability in the activation of caged fluorophores and prodrugs, and the possibilities of using external stimuli to release therapeutic substances at a specific location in a diseased tissue are discussed. Finally, we highlight frontiers in the field, identifying challenges, and propose directions for future development in this emerging field.
PB Angewandte Chemie International Edition
SN 14337851
YR 2023
FD 2023-03-01
LK http://hdl.handle.net/11093/4624
UL http://hdl.handle.net/11093/4624
LA eng
NO Angewandte Chemie International Edition, 62(10): e2022154 (2023)
NO Agencia Estatal de Investigación | Ref. PID2020-113704RB-I00
DS Investigo
RD 08-dic-2023