RT Dissertation/Thesis
T1 Screening of macroalgae for the production of bioactive compounds. Optimization of fucoxanthin extraction from Undaria pinnatifida and evaluation of its biological properties for industrial applications.
T2 Estudio de macroalgas como fuente de compuestos bioactivos. Optimización de la extracción de fucoxantina a partir de Undaria pinnatifida y evaluación de sus propiedades biológicas para aplicaciones industriales.
A1 Santos Pires Lourenco Lopes, Catarina
K1 2417.07 Algología (Ficología)
K1 2301 Química Analítica
K1 3303.03 Procesos Químicos
AB The aim of this study is to optimize the extraction and purification of the fucoxanthin molecule that can be obtained from Algae matrices, especially from brown ones, also known as Phaeophyceae. Algae are a great vegetative resource that has been characterized, showing a high content in proteins, carbohydrates and minerals, but more importantly, in very diverse secondary metabolites like phenolic compounds and carotenes, making them a very interesting natural source for new ingredients. Being one of them fucoxanthin, one of the major carotenoids found in algae. Its structure includes an allenic bond and functional carbonyl, hydroxyl and carboxyl moieties that can be responsible for fucoxanthin’s diverse properties. Considering that industrial scale production of this molecule presents several difficulties and is not efficient enough for the commercial scale, it is of relevant interest to optimize a process of extraction and purification of this compound starting from a raw material, such as algae, that can achieve its production in larger doses. Fucoxanthin has gather much attention lately due to its strong antioxidant proprieties, anticancer and anti-inflammatory activities, as well as citoprotective, antiobesity, neuroprotective and skin protective effects. These results imply that fucoxanthin has great potential to be included in a nutritional supplement for the prevention and treatment of obesity and a wide variety of related pathologies, like metabolic syndrome, type 2 diabetes, and heart disease.Therefore, this study intends to experiment with several extraction methods and different solvents, to gather information about the various types of extractions in order to choose the best procedure to obtain fucoxanthin, as well as study some of the bioactivities previously reported, in order to incorporate the active extract to functional super food formulations.Considering that industrial scale production of this molecule presents several difficulties and is not efficient enough for the commercial scale, it is of relevant interest to optimize a process of extraction and purification of this compound starting from a raw material, such as algae, that can achieve its production in larger doses. Fucoxanthin has gather much attention lately due to its strong antioxidant proprieties, anticancer and anti-inflammatory activities, as well as citoprotective, antiobesity, neuroprotective and skin protective effects. These results imply that fucoxanthin has great potential to be included in a nutritional supplement for the prevention and treatment of obesity and a wide variety of related pathologies, like metabolic syndrome, type 2 diabetes, and heart disease.It is also important to verify the stability of the molecule as well as its bioavailability and toxicity in the human body so that it can be administered in the best possible way to obtain the highest results, as it appears to have in the in vitro and in vivo models studied. As such, this study intends to experiment with several extraction methods and different solvents, to gather information about the various types of extractions in order to choose the best procedure to obtain fucoxanthin, as well as study its stability and some of the bioactivities previously reported, in order to verify its efficacy and safety.
LK http://hdl.handle.net/11093/4872
UL http://hdl.handle.net/11093/4872
LA por
DS Investigo
RD 13-sep-2024