RT Journal Article
T1 Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays
A1 Figueiredo González, María
A1 Reboredo Rodríguez, Patricia
A1 González Barreiro, Carmen
A1 Simal Gándara, Jesús
A1 Valentão, Patrícia
A1 Carrasco Pancorbo, Alegría
A1 Andrade, Paula B
A1 Cancho Grande, Beatriz
K1 3309.28 Aceites y Grasas Vegetales
K1 3309.20 Propiedades de Los Alimentos
K1 3309.03 Antioxidantes en Los Alimentos
AB In this work, phenol-rich extracts from ‘Cornicabra’ and ‘Picual’ virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (α-glucosidase and α-amylase). ‘Cornicabra’ displayed the best inhibitory activity against all enzymes, when compared to ‘Picual’: BuChE (IC50 = 156 ± 4 and 308 ± 33 mg mL−1), LOX (IC50 = 26 ± 0.5 and 37 ± 3 mg mL−1), hMAO-A (IC50 = 20 ± 2 and 37 ± 0.2 mg mL−1), hMAO-B (IC50 = 131 ± 7 and 215 ± 13 mg mL−1) and α-glucosidase (IC50 = 154 ± 17 and 251 ± 31 mg mL−1), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in ‘Cornicabra’ EVOO.
PB Food Research International
SN 09639969
YR 2018
FD 2018-04
LK http://hdl.handle.net/11093/6174
UL http://hdl.handle.net/11093/6174
LA eng
NO Food Research International, 106, 558-567 (2018)
NO POCTEP | Ref. 0377_IBERPHENOL_6_E
DS Investigo
RD 16-sep-2024