RT Journal Article
T1 Oral administration of melatonin counteracts several of the effects of chronic stress in rainbow trout
A1 Conde Sieira, Marta
A1 Pérez Muñoz, J. L
A1 López Patiño, Marcos Antonio
A1 Gesto Rodríguez, Manuel
A1 Soengas Fernández, José Luis
A1 Míguez Miramontes, Jesús Manuel
K1 2401.13 Fisiología Animal
K1 3105 Peces y Fauna Silvestre
AB To assess a possible antistress role of melatonin in fish, we orally administered melatonin to rainbow trout for 10 d and then kept the fish under normal or high stocking density conditions during the last 4 d. Food intake; biochemical parameters in plasma (cortisol, glucose, and lactate concentrations); liver (glucose and glycogen concentrations, and glycogen synthase activity); enzyme activities of amylase, lipase, and protease in foregut and midgut; and content of the hypothalamic neurotransmitters dopamine and serotonin, as well as their oxidized metabolites, 3,4-dihydroxyphenylacetic acid and 5-hydroxy-3-indoleacetic acid, were evaluated under those conditions. High stocking density conditions alone induced changes indicative of stress conditions in plasma cortisol concentrations, liver glycogenolytic potential, the activities of some digestive enzymes, and the 3,4-dihydroxyphenylacetic acid-to-dopamine and 5-hydroxy-3-indoleacetic acid-to-serotonin ratios in the hypothalamus. Melatonin treatment in nonstressed fish induced an increase in liver glycogenolytic potential, increased the activity of some digestive enzymes, and enhanced serotoninergic and dopaminergic metabolism in hypothalamus. The presence of melatonin in stressed fish resulted in a significant interaction with cortisol concentrations in plasma, glycogen content, and glycogen synthase activity in liver and dopaminergic and serotoninergic metabolism in the hypothalamus. In general, the presence of melatonin mitigated several of the effects induced by stress, supporting an antistress role for melatonin in rainbow trout.
PB Domestic Animal Endocrinology
SN 07397240
YR 2014
FD 2014-01
LK http://hdl.handle.net/11093/6229
UL http://hdl.handle.net/11093/6229
LA eng
NO Domestic Animal Endocrinology, 46(2014): 26-36 (2014)
NO Ministerio de Ciencia e Innovación | Ref. AGL2010-22247-C03-03
DS Investigo
RD 17-sep-2024