RT Journal Article
T1 GraftFast surface engineering to improve MOF nanoparticles furtiveness
A1 Giménez Marqués, Mónica
A1 Bellido, Elena
A1 Berthelot, Thomas
A1 Simón Yarza, Teresa
A1 Hidalgo, Tania
A1 Simón Vázquez, Rosana
A1 González Fernández, Maria Africa
A1 Ávila, José
A1 Asensio, María Carmen
A1 Gref, Ruxandra
A1 Couvreur, Patrick
A1 Serre, Christian
A1 Horcajada, Patricia
K1 2307 Química Física
K1 2412.07 Inmunoquímica
AB Controlling the outer surface of nanometric metal–organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL-100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF–PEG interaction is deeply investigated using high-resolution soft X-ray spectroscopy. Finally, a cell penetration study using the radio-labeled antitumor agent gemcitabine monophosphate (3H-GMP)-loaded MIL-100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.
PB Small
SN 16136810
YR 2018
FD 2018-10-04
LK http://hdl.handle.net/11093/6344
UL http://hdl.handle.net/11093/6344
LA eng
NO Small, 14(40): 1-11 (2018)
NO Agence Nationale de la Recherche | Ref. ANR‐10‐LABX‐0035
DS Investigo
RD 08-sep-2024