RT Dissertation/Thesis T1 Valorization of the invasive algae "Sargassum muticum" Yendo (Fensholt) by obtaining active fractions for cosmetic and pharmaceutical use T2 Valorización del alga invasora "Sargassum muticum" Yendo (Fensholt) mediante la obtención de fracciones activas para uso cosmético y farmacéutico A1 Balboa Alfaya, Elena Maria K1 3328.25 Extracción Sólido - Líquido K1 3209.04 Medicamentos Naturales K1 3308.02 Residuos Industriales AB The present PhD thesis shows a proposal of valorization of the invasive alga "S. muticum" including several processes to obtain and purify bioactive compounds and some of their applications. Extraction and fractionation steps have been tested and optimized, the obtained fractions and compounds were characterized and their potential as cosmetic and pharmaceutical ingredients were determined. Utilized processes and obtained streams were integrated and connected under the biorefinery concept, due to minimize the waste production, maximize subproducts advantage and increase the yield of high-added value products. In addition, the colaboration with other research centers by short-term researchs or work colaboration, a compound was isolated and its structure was elucidated. Obtained compound, extracts and fractions were tested in vitro for photodamage attenuation capacity in UVA irradiated dermal cells, for anti-tumoral capacity in cancer cells, and as antioxidant agents in cosmetics formulations stability assays. There are some works describing the use of different components of the algal biomass and, probably, there are still new applications to discover in cosmetics and pharmaceutics. Several studies are needed to complete and make progresses on this proposal of S. muticum valorization. YR 2016 FD 2016-01-22 LK http://hdl.handle.net/11093/643 UL http://hdl.handle.net/11093/643 LA eng NO Ministerio de Educación y Ciencia | Ref. BES 2010-041807 DS Investigo RD 17-sep-2024