TY  - JOUR 
AU  - Trinidad López, Carmen
AU  - De La Fuente Aguado, Javier
AU  - Oca Pernas, Roque
AU  - Delgado Sánchez-Gracián, Carlos
AU  - Santos Armentia, Eloisa
AU  - Vaamonde Liste, Andres Antonio
AU  - Prada González, Raquel
AU  - Souto Bayarri, Miguel
PY  - 2019
SN  - 25099280
UR  - http://hdl.handle.net/11093/3418
AB  - BACKGROUND: To evaluate changes in perfusion computed tomography (PCT) parameters induced by treatment with conventional chemotherapy (CCT) alone or with CCT and radiation therapy (RT) in patients with non-small cell lung cancer (NSCLC) and to...
AB  - METHODS: Fifty-three patients with a histological diagnosis of NSCLC prospectively underwent PCT of the whole tumour, before/after CCT or before/after CCT and RT. Blood flow (BF), blood volume (BV), permeability (PMB), and mean transit time (MTT) were...
AB  - RESULTS: PCT parameters decreased after treatment, significantly for BV (p = 0.002) and MTT (p = 0.027). The 30 patients with partial response had a significant decrease of 21% for BV (p = 0.006) and 17% for MTT (p = 0.031). A non-significant decrease...
AB  - CONCLUSIONS: Treatment of NSCLC with platinum derivatives, with or without RT, induces changes in PCT parameters. Partial response is associated with a significant decrease in BV and MTT, attributable to the effect of the treatment on tumour...
LA  - eng
PB  - European radiology experimental
TI  - Evaluation of response to conventional chemotherapy and radiotherapy by perfusion computed tomography in non-small cell lung cancer (NSCLC)
DO  - 10.1186/s41747-019-0101-x
ER  -